Tropomyosin isoforms in rat neurons: the different developmental profiles and distributions of TM-4 and TMBr-3 are consistent with different functions.

@article{Had1994TropomyosinII,
  title={Tropomyosin isoforms in rat neurons: the different developmental profiles and distributions of TM-4 and TMBr-3 are consistent with different functions.},
  author={L Had and Catherine Faivre-Sarrailh and Chantal Legrand and J. Ph. Mery and J Brugidou and Alain Rabi{\'e}},
  journal={Journal of cell science},
  year={1994},
  volume={107 ( Pt 10)},
  pages={2961-73}
}
Antipeptide antisera specific for TM-4 and TMBr-3, the two tropomyosin isoforms in neurons, were used to investigate the concentrations and distributions of these F-actin-binding proteins in neurons in vitro and in vivo. TM-4 and TMBr-3 tropomyosins had different developmental profiles. TM-4 was found mainly in immature stages, while the concentration of TMBr-3 increased with maturation. The two isoforms also had different subcellular distributions. TM-4 was concentrated in the growth cones of… CONTINUE READING