Tropomyosin and gelsolin cooperate in controlling the microfilament system.

@article{NykernMeazza2002TropomyosinAG,
  title={Tropomyosin and gelsolin cooperate in controlling the microfilament system.},
  author={Maria Ny{\aa}kern-Meazza and Kartik Narayan and Clarence Schutt and Uno Lindberg},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 32},
  pages={28774-9}
}
Tropomyosin has been shown to cause annealing of gelsolin-capped actin filaments. Here we show that tropomyosin is highly efficient in transforming even the smallest gelsolin-actin complexes into long actin filaments. At low concentrations of tropomyosin, the effect of tropomyosin depends on the length of the actin oligomer, and the cooperative nature of the process is a direct indication that tropomyosin induces a conformational change in the gelsolin-actin complexes, altering the structure at… CONTINUE READING

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