Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver.

Abstract

Tropomodulin (Tmod) is a protein that binds and caps the pointed ends of actin filaments in erythroid and nonerythoid cell types. Targeted deletion of mouse tropomodulin3 (Tmod3) leads to embryonic lethality at E14.5-E18.5, with anemia due to defects in definitive erythropoiesis in the fetal liver. Erythroid burst-forming unit and colony-forming unit… (More)
DOI: 10.1182/blood-2013-03-492710

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@article{Sui2014Tropomodulin3nullMA, title={Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver.}, author={Zhenhua Sui and Roberta B. Nowak and Andrea Bacconi and Nancy E. Kim and Hui Liu and Jie Li and Amittha Wickrema and Xiu-li An and Velia M Fowler}, journal={Blood}, year={2014}, volume={123 5}, pages={758-67} }