Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling

@inproceedings{Lim2015Tropomodulin3IA,
  title={Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling},
  author={Chun-Yan Lim and Xuezhi Bi and Donghai Wu and Jae Bum Kim and Peter W Gunning and Wanjin Hong and Weiping Han},
  booktitle={Nature communications},
  year={2015}
}
Akt2 and its downstream effectors mediate insulin-stimulated GLUT4-storage vesicle (GSV) translocation and fusion with the plasma membrane (PM). Using mass spectrometry, we identify actin-capping protein Tropomodulin 3 (Tmod3) as an Akt2-interacting partner in 3T3-L1 adipocytes. We demonstrate that Tmod3 is phosphorylated at Ser71 on insulin-stimulated Akt2 activation, and Ser71 phosphorylation is required for insulin-stimulated GLUT4 PM insertion and glucose uptake. Phosphorylated Tmod3… CONTINUE READING
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A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 translocation in mouse skeletal muscle

N Takenaka
FEBS J. 281, • 2014

traffic control of GLUT4

D. Leto, Saltiel, A. R. Regulation of glucose transport by insulin
Nat. Rev. Mol. Cell Biol. 13, 383–396 • 2012