Tropolone alkaloids from Colchicum kurdicum (Bornm.) Stef. (Colchicaceae) as the potent novel antileishmanial compounds; purification, structure elucidation, antileishmanial activities and molecular docking studies.

@article{Azadbakht2020TropoloneAF,
  title={Tropolone alkaloids from Colchicum kurdicum (Bornm.) Stef. (Colchicaceae) as the potent novel antileishmanial compounds; purification, structure elucidation, antileishmanial activities and molecular docking studies.},
  author={M. Azadbakht and A. Davoodi and S. Hosseinimehr and M. Keighobadi and M. Fakhar and R. Valadan and R. Faridnia and S. Emami and Adel Bakhtiyari},
  journal={Experimental parasitology},
  year={2020},
  pages={
          107902
        }
}
Natural compounds played an important role for prevention and treatment of the disease as well as are the important compounds for the design of the new bioactive compounds. In this study, eight tropolone alkaloids were isolated from Colchicum kurdicum including colchicoside, 2-demethyl colchicine, 3-demethyl colchicine, demecolcine, colchifoline, N-deacetyl-N-formyl colchicine, colchicine and cornigerine by column and preparative thin layer chromatography. The chemical structures were… Expand

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