Tropoelastin modulates TGF-β1-induced expression of VEGF and CTGF in airway smooth muscle cells.

@article{Reddel2013TropoelastinMT,
  title={Tropoelastin modulates TGF-β1-induced expression of VEGF and CTGF in airway smooth muscle cells.},
  author={Caroline J Reddel and Daniele Cultrone and Jelena Rnjak-Kovacina and Anthony S Weiss and Janette K Burgess},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2013},
  volume={32 7-8},
  pages={407-13}
}
Elastin is predominantly comprised of crosslinked tropoelastin. For many years elastin was considered to serve a solely structural role but is now being increasingly identified as causal in cell signaling, development and repair. We introduced tropoelastin into an in vitro model in which airway smooth muscle cells (ASMCs) were stimulated with transforming growth factor (TGF)-β1 to examine the modulatory effect of this modular elastin sequence on release of angiogenic factors and matrix… CONTINUE READING
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