Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts.

  title={Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts.},
  author={Tadahisa Sugiura and Riddhima Agarwal and Shuhei Tara and Tai Yi and Y. U. Lee and Christopher K. Breuer and Anthony S Weiss and Toshiharu Shinoka},
  journal={Acta biomaterialia},
Neointimal hyperplasia, which results from the activation, proliferation and migration of vascular smooth muscle cells (SMCs), is a detrimental condition for vascular stents or vascular grafts that leads to stenosis. Preventing neointimal hyperplasia of vascular grafts is critically important for the success of arterial vascular grafts. We hypothesized that tropoelastin seeding onto the luminal surface of the graft would prevent neointimal hyperplasia through suppressing neointimal smooth… CONTINUE READING
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