Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining.

@article{Balsitis2009TropismOD,
  title={Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining.},
  author={Scott J Balsitis and Jos{\'e}fina Coloma and Glenda Castro and Aracely Alava and Diana Flores and James H McKerrow and P. Robert Beatty and Eva Harris},
  journal={The American journal of tropical medicine and hygiene},
  year={2009},
  volume={80 3},
  pages={
          416-24
        }
}
Previous attempts to define dengue virus (DENV) tropism in human autopsy tissues have detected DENV antigens that are abundant in circulation during severe dengue, and thus may be present in uninfected cells. To better define DENV tropism, we performed immunostaining for the DENV2 nonstructural protein 3 (NS3) in humans and in a mouse model of DENV infection. In mice, NS3 was detected in phagocytes of the spleen and lymph node, hepatocytes in liver, and myeloid cells in bone marrow. In human… CONTINUE READING

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