Tropisetron attenuated the anxiogenic effects of social isolation by modulating nitrergic system and mitochondrial function.

@article{Amiri2015TropisetronAT,
  title={Tropisetron attenuated the anxiogenic effects of social isolation by modulating nitrergic system and mitochondrial function.},
  author={S. Amiri and Hossein Amini-Khoei and A. Haj‐Mirzaian and M. Rahimi-Balaei and P. Naserzadeh and Ahmadreza Dehpour and S. E. Mehr and M. Hosseini},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1850 12},
  pages={
          2464-75
        }
}
  • S. Amiri, Hossein Amini-Khoei, +5 authors M. Hosseini
  • Published 2015
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • BACKGROUND Early social isolation stress (SIS) is associated with the occurrence of anxiety behaviors. It seems interaction between the nitrergic system and mitochondrial function plays a role in mediating the anxiety-like behaviors. In this study, we aimed to investigate the anxiolytic effects of tropisetron in animal model of SIS and we try to illustrate the possible role of nitrergic system and mitochondrial function. METHODS We applied early social isolation paradigm to male NMRI mice… CONTINUE READING
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