Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations.

@article{Bhatia2002TropicalCP,
  title={Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations.},
  author={Eesh Bhatia and Gourdas Choudhuri and Sadiq Saleem Sikora and Olfert Landt and Andreas Kage and Michael P.I. Becker and Heiko Witt},
  journal={Gastroenterology},
  year={2002},
  volume={123 4},
  pages={1020-5}
}
BACKGROUND & AIMS Tropical calcific pancreatitis (TCP) is a chronic pancreatitis unique to developing countries in tropical regions. The cause of TCP is obscure. Whereas environmental factors, such as protein energy malnutrition and ingestion of cassava, have been implicated, a genetic predisposition to the disease also may be important. In the present study we report on mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene in north Indian patients with TCP. METHODS We… CONTINUE READING