Trophoblastic giant cells of the mouse placenta as the site of proliferin synthesis.

@article{Lee1988TrophoblasticGC,
  title={Trophoblastic giant cells of the mouse placenta as the site of proliferin synthesis.},
  author={Seon Jin Lee and Frank J Talamantes and Elizabeth L. Wilder and Daniel I. H. Linzer and Daniel Nathans},
  journal={Endocrinology},
  year={1988},
  volume={122 5},
  pages={1761-8}
}
Proliferin (PLF) is a PRL-related glycoprotein secreted by a number of mouse cell lines and by minced mouse placenta. To further investigate the hormone-like characteristics of PLF, we have determined the site of PLF synthesis and storage in the placenta and its concentration in blood serum during pregnancy. By immunohistochemical staining and in situ hybridization PLF protein and messenger RNA (mRNA) were localized to the trophoblastic giant cells. Individual cells contained both PLF and… CONTINUE READING

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