Trophoblastic disease monitoring: Evaluation of pregnancy-specific beta 1-glycoprotein.

  title={Trophoblastic disease monitoring: Evaluation of pregnancy-specific beta 1-glycoprotein.},
  author={Timothy J O'brien and Eva Engvall and John B Schlaerth and Colette Morrow},
  journal={American journal of obstetrics and gynecology},
  volume={138 3},
Pregnancy-specific beta 1-glycoprotein (SP1) was evaluated as a potential marker protein for monitoring trophoblastic disease. Four patients with post-molar pregnancy accompanied by spontaneous titer remission and three patients with nonmetastatic trophoblastic disease were found to have regression curves for both human chorionic gonadotropin (hCG) and SP, which closely followed each other. Of three patients with metastatic choriocarcinoma, two were shown to have discordant hCG and SP1 patterns… CONTINUE READING

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