Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase.

@article{Abell2009TrophoblastSC,
  title={Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase.},
  author={Amy N. Abell and Deborah A. Granger and Nancy Lassignal Johnson and Nicole Vincent-Jordan and Christopher F. Dibble and Gary Leon Johnson},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 10},
  pages={2748-61}
}
Trophoblast differentiation during placentation involves an epithelial-mesenchymal transition (EMT) with loss of E-cadherin and gain of trophoblast invasiveness. Mice harboring a point mutation that renders inactive the mitogen-activated protein kinase kinase kinase MEKK4 exhibit dysregulated placental development with increased trophoblast invasion. Isolated MEKK4 kinase-inactive trophoblast stem (TS) cells cultured under undifferentiating, self-renewing conditions in the presence of… CONTINUE READING

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