Trophoblast-derived chemokine CXCL12 promotes CXCR4 expression and invasion of human first-trimester decidual stromal cells.

@article{Ren2012TrophoblastderivedCC,
  title={Trophoblast-derived chemokine CXCL12 promotes CXCR4 expression and invasion of human first-trimester decidual stromal cells.},
  author={Liang Ren and Yong-Qiao Liu and Wen-hui Zhou and Yuan-zhen Zhang},
  journal={Human reproduction},
  year={2012},
  volume={27 2},
  pages={366-74}
}
BACKGROUND The aim of this study was to investigate the role of the chemokine (C-X-C motif) ligand 12/chemokine (C-X-C motif) receptor 4 (CXCL12/CXCR4) axis on the crosstalk between human first-trimester trophoblast cells (TCs) and decidual stromal cells (DSCs), to contribute to a better understanding of the molecular mechanisms on the interaction between the mother and embryo during pregnancy. METHODS CXCR4 on human first-trimester DSC membranes was detected by flow cytometry. The effects of… CONTINUE READING
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and altered expression of proteins in the p 53 pathway in villous trophoblast

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