Trophoblast L-Selectin-Mediated Adhesion at the Maternal-Fetal Interface

@article{Genbacev2003TrophoblastLA,
  title={Trophoblast L-Selectin-Mediated Adhesion at the Maternal-Fetal Interface},
  author={O. Genbacev and A. Prakobphol and R. Foulk and Ana Krtolica and D. Ili{\'c} and M. Singer and Zhi-qiang Yang and L. Kiessling and S. D. Rosen and S. Fisher},
  journal={Science},
  year={2003},
  volume={299},
  pages={405 - 408}
}
  • O. Genbacev, A. Prakobphol, +7 authors S. Fisher
  • Published 2003
  • Biology, Medicine
  • Science
  • Trophoblast adhesion to the uterine wall is the requisite first step of implantation and, subsequently, placentation. At the maternal-fetal interface, we investigated the expression of selectin adhesion systems that enable leukocyte capture from the bloodstream. On the maternal side, human uterine epithelial cells up-regulated selectin oligosaccharide-based ligands during the window of receptivity. On the fetal side, human trophoblasts expressed L-selectin. This ligand-receptor system was… CONTINUE READING
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