Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro

@article{Shindler1998TrophicSP,
  title={Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro},
  author={Kenneth S Shindler and Anne Marie R. Yunker and Rael Cahn and Jiping Zha and S Stanley J. Korsmeyer and Kevin A. Roth},
  journal={Cell Death and Differentiation},
  year={1998},
  volume={5},
  pages={901-910}
}
Survival of immature neurons is regulated by Bcl-xL, as targeted disruption of bcl-x significantly increases cell death in vivo and in vitro. Death of cultured bcl-x-deficient and wild-type telencephalic cells can be prevented by fetal calf serum or chemically-defined medium (ITS), suggesting trophic factors in these media potentiate survival through a pathway independent of Bcl-xL. Addition of trophic factors to basal medium revealed that insulin and insulin-like growth factors (IGFs), but not… CONTINUE READING