Trophic macrophages in development and disease

  title={Trophic macrophages in development and disease},
  author={Jeffrey W Pollard},
  journal={Nature Reviews Immunology},
Specialized phagocytes are found in the most primitive multicellular organisms. Their roles in homeostasis and in distinguishing self from non-self have evolved with the complexity of organisms and their immune systems. Equally important, but often overlooked, are the roles of macrophages in tissue development. As discussed in this Review, these include functions in branching morphogenesis, neuronal patterning, angiogenesis, bone morphogenesis and the generation of adipose tissue. In each case… CONTINUE READING
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