Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF).

  title={Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF).},
  author={Giuseppe Pintucci and Scott H Froum and Jared Pinnell and Paolo Mignatti and Shahin Rafii and David Green},
  journal={Thrombosis and haemostasis},
  volume={88 5},
In addition to their role in primary hemostasis, platelets serve to support and maintain the vascular endothelium. [] Key Result The survival and proliferation of endothelial cells were markedly stimulated (2-3-fold and 5-15-fold respectively) by the addition of gel-filtered platelets. Acetylsalicylic acid-treated or lyophilized fixed-platelets were ineffective in supporting endothelial cell proliferation.

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