Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF).

@article{Pintucci2002TrophicEO,
  title={Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF).},
  author={Giuseppe Pintucci and Scott H. Froum and Jared Pinnell and Paolo Mignatti and Shahin Rafii and David Vincent Green},
  journal={Thrombosis and haemostasis},
  year={2002},
  volume={88 5},
  pages={834-42}
}
In addition to their role in primary hemostasis, platelets serve to support and maintain the vascular endothelium. Platelets contain numerous growth factors including the potent angiogenic inducers VEGF and FGF-2. To characterize the function of these two platelet-associated growth factors, the effects of the addition of purified platelets to cultured endothelial cells were examined. The survival and proliferation of endothelial cells were markedly stimulated (2-3-fold and 5-15-fold… CONTINUE READING

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