Trophic effects of estradiol on fetal rat hypothalamic neurons.

  title={Trophic effects of estradiol on fetal rat hypothalamic neurons.},
  author={Julie A Chowen and Ign{\'a}cio Torres-Aleman and Luis-Miguel Garcia-Segura},
  volume={56 6},
Sex steroids play an important role in the development and functioning of the central nervous system (CNS); however, the mechanisms by which such hormones exert these effects are not well understood. We addressed the question as to whether sex steroids affect the development of the hypothalamus, at least in part, by acting as a trophic factor to modulate the number of neurons in the hypothalamus. To this end, primary hypothalamic cultures were prepared from the brains of embryonic (day 15… CONTINUE READING