Trop2 regulates motility and lamellipodia formation in cultured fetal lung fibroblasts.

Abstract

Proliferation and migration of fibroblasts are vital for fetal lung development. However, the regulatory mechanisms are poorly understood. We have previously shown that TROP2 gene expression is closely associated with fetal lung cell proliferation in vivo and that TROP2 knockdown decreases proliferation of fetal lung fibroblasts in culture. We hypothesized… (More)
DOI: 10.1152/ajplung.00160.2012

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