Trojan horse effect: phagocyte-mediated Streptococcus iniae infection of fish.

@article{Zlotkin2003TrojanHE,
  title={Trojan horse effect: phagocyte-mediated Streptococcus iniae infection of fish.},
  author={Amir Zlotkin and Stefan Chilmonczyk and Marina Eyngor and Avshalom Hurvitz and Claudio Ghittino and Avi Eldar},
  journal={Infection and immunity},
  year={2003},
  volume={71 5},
  pages={2318-25}
}
The salmonid macrophage-like cell line RTS-11 and purified trout pronephros phagocytes were used to analyze in vitro entry and survival of two Streptococcus iniae serotypes. Efficient invasion by S. iniae occurred in both cells, but only the type II strain persisted in pronephros phagocytes for at least 48 h. Ex vivo models of opsonin-dependent phagocytosis by pronephros phagocytes demonstrated increased phagocytosis efficacy. Analysis of phagocytes collected from diseased fish demonstrated… CONTINUE READING