Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells.

@article{Bova2005TroglitazoneIA,
  title={Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells.},
  author={Michael P. Bova and Danny W H Tam and Gerald McMahon and Matthew N Mattson},
  journal={Toxicology letters},
  year={2005},
  volume={155 1},
  pages={41-50}
}
Troglitazone, a thiazolidinedione containing compound, was widely used to treat non-insulin dependent-diabetes. Unfortunately, troglitazone was associated with a sporadic liver toxicity that led to a cessation of its use clinically. Here we show that troglitazone induces a rapid and dose-dependent drop of mitochondrial membrane potential in liver HepG2 cells. The decrease in mitochondrial membrane potential induced by 100 microM troglitazone was completed after 5 min and similar in magnitude to… CONTINUE READING