Troglitazone Attenuates TGF-β1-Induced EMT in Alveolar Epithelial Cells via a PPARγ-Independent Mechanism

@inproceedings{Zhou2012TroglitazoneAT,
  title={Troglitazone Attenuates TGF-β1-Induced EMT in Alveolar Epithelial Cells via a PPARγ-Independent Mechanism},
  author={Beiyun Zhou and S T Buckley and Vipul Patel and Yixin Liu and Jiao Luo and Manda Sai Krishnaveni and Mihaela V Ivan and Lucas Demaio and K. W. Kim and Carsten Ehrhardt and Edward D Crandall and Zea Borok},
  booktitle={PloS one},
  year={2012}
}
Peroxisome proliferator activated receptor γ (PPARγ) agonists are effective antifibrotic agents in a number of tissues. Effects of these agents on epithelial-mesenchymal transition (EMT) of primary alveolar epithelial cells (AEC) and potential mechanisms underlying effects on EMT have not been well delineated. We examined effects of troglitazone, a synthetic PPARγ agonist, on transforming growth factor (TGF)-β1-induced EMT in primary rat AEC and an alveolar epithelial type II (AT2) cell line… CONTINUE READING
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