TrnR2, a Novel Receptor That Mediates Neurturin and GDNF Signaling through Ret

  title={TrnR2, a Novel Receptor That Mediates Neurturin and GDNF Signaling through Ret},
  author={Robert H Baloh and Mal{\'u} G. Tansey and Judith P. Golden and Douglas J. Creedon and Robert O Heuckeroth and Catherine L. Keck and Drazen B. Zimonjic and Nicholas C. Popescu and Eugene Malcolm Johnson and Jeffrey D. Milbrandt},
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) comprise a family of TGF-beta-related neurotrophic factors (TRNs), which have trophic influences on a variety of neuronal populations. A receptor complex comprised of TrnR1 (GDNFR alpha) and Ret was recently identified and found to be capable of mediating both GDNF and NTN signaling. We have identified a novel receptor based on homology to TrnR1, called TrnR2, that is 48% identical to TrnR1, and is located on the short arm… CONTINUE READING
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