Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor

  title={Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor},
  author={David J. Glass and Steven H. Nye and Petros A. Hantzopoulos and Mary J. Macchi and Stephen P. Squinto and Mitchell Goldfarb and George D. Yancopoulos},
Early BDNF, NT-3, and NT-4 Signaling Events
Using TrkB-expressing cells, it is found that BDNF and NT-4 individually induced tyrosine phosphorylation of TrkB in a dose-dependent fashion and these data suggest that the earliest signaling events for BDNF, NT-3, andNT-4 are very similar to those for NGF.
The Trk family of neurotrophin receptors.
Preliminary characterization of these mutant mice has provided significant information regarding the role of these receptors in the ontogeny of the mammalian nervous system, and TrkC-deficient mice display strikingly abnormal movements consistent with loss of proprioception.
Neurotrophin dependence mediated by p75NTR: contrast between rescue by BDNF and NGF
The hypothesis that p75NTR is a mediator of neurotrophin dependence during the critical phase of developmental cell death and during the progression of carcinogenesis in prostate cancer is supported.
Differential Modulation of Neuron Survival during Development by Nerve Growth Factor Binding to the p75 Neurotrophin Receptor*
Nerve growth factor (NGF) supports the survival and differentiation of distinct populations of peripheral and central neurons. NGF binds to two classes of cell-surface receptors, the protein tyrosine
Structural and Functional Properties of the TRK Family of Neurotrophin Receptors
  • M. Barbacid
  • Biology
    Annals of the New York Academy of Sciences
  • 1995
Characterization of mutant mice lacking each of these tyrosine-kinase receptors by gene targeting in embryonic stem cells is providing relevant information regarding the critical role that these receptors play in the ontogeny of the mammalian nervous system.


Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.
The distribution of NT-3 messenger RNA and its biological activity on a variety of neuronal populations clearly distinguishNT-3 from NGF and BDNF, and provide compelling evidence that NT- 3 is an authentic neurotrophic factor that has its own characteristic role in vivo.
Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo
Brain-derived neurotrophic factor (BDNF), a protein known to support the survival of embryonic sensory neurons and retinal ganglion cells, was derivatized with 125I-Bolton-Hunter reagent and obtained
Molecular cloning and expression of brain-derived neurotrophic factor
The full primary structure of brain-derived neurotrophic factor is reported and it is established that these two neurotrophic factors are related both functionally and structurally.
Expression of functional nerve growth factor receptors after gene transfer.
Findings support the hypothesis that a single binding protein is common to both forms of the NGF receptor and suggest that an additional protein is required to produce the high affinity form of theNGF receptor.
Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.
A pool of degenerate oligonucleotides representing all possible codons in regions of homology between brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) to prime rat hippocampal cDNAs to represent a family of neurotrophic factors that may cooperate to support the development and maintenance of the vertebrate nervous system.
Molecular investigations on the high-affinity nerve growth factor receptor