TrkB signaling directs the incorporation of newly generated periglomerular cells in the adult olfactory bulb.

@article{Bergami2013TrkBSD,
  title={TrkB signaling directs the incorporation of newly generated periglomerular cells in the adult olfactory bulb.},
  author={Matteo Bergami and Beatrice Vignoli and Elisa Motori and Simone Pifferi and Emanuela Zuccaro and Anna Menini and Marco Canossa},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 28},
  pages={11464-78}
}
In the adult rodent brain, the olfactory bulb (OB) is continuously supplied with new neurons which survival critically depends on their successful integration into pre-existing networks. Yet, the extracellular signals that determine the selection which neurons will be ultimately incorporated into these circuits are largely unknown. Here, we show that immature neurons express the catalytic form of the brain-derived neurotrophic factor receptor TrkB [full-length TrkB (TrkB-FL)] only after their… CONTINUE READING
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