TrkB receptor signaling regulates developmental death dynamics, but not final number, of retinal ganglion cells.

@article{Pollock2003TrkBRS,
  title={TrkB receptor signaling regulates developmental death dynamics, but not final number, of retinal ganglion cells.},
  author={Graeme S Pollock and Regine Robichon and Kristina A Boyd and Kristi A Kerkel and Melissa Kramer and Johnalyn Lyles and Ranjini Ambalavanar and Asema Khan and David R Kaplan and Robert W. Williams and Douglas O. Frost},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 31},
  pages={10137-45}
}
We investigated the effects of endogenous neurotrophin signaling on the death-survival of immature retinal ganglion cells (RGCs) in vivo. Null mutation of brain-derived neurotrophic factor [(BDNF) alone or in combination with neurotrophin 4 (NT4)] increases the peak rate of developmental RGC death as compared with normal. Null mutation of NT4 alone is ineffective. Null mutation of the full-length trkB (trkBFL) receptor catalytic domain produces a dose-dependent increase in the peak RGC death… CONTINUE READING

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