TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease.

@article{Gao2016TrkBAB,
  title={TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease.},
  author={Lei Gao and Mi Tian and Hong-yun Zhao and Qian-qian Xu and Yu-Ming Huang and Qun-Cao Si and Q. I. Tian and Qing-ming Wu and Xia-min Hu and Li-Bo Sun and Shawn M. McClintock and Yan Zeng},
  journal={Journal of neurochemistry},
  year={2016},
  volume={136 3},
  pages={620-36}
}
We recently demonstrated that activation of tyrosine receptor kinase B (TrkB) by 7, 8-dihydroxyflavone (7, 8-DHF), the selective TrkB agonist, increased surface alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors (AMPARs) AMPA receptor subunit GluR1 (GluA1) subunit expression at the synapses of Fragile X Syndrome mutant mice. This present study investigated the effects of 7, 8-DHF on both memory function and synapse structure in relation to the synapse protein level of… CONTINUE READING