TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry.

Abstract

Dysfunction of basal forebrain cholinergic neurons (BFCNs) is an early pathological hallmark of Alzheimer's disease (AD). Numerous studies have indicated that nerve growth factor (NGF) supports survival and phenotypic differentiation of BFCNs. Consistent with a potential link to AD pathogenesis, TrkA, a NGF receptor, is expressed in cholinergic forebrain… (More)
DOI: 10.1523/JNEUROSCI.6314-11.2012

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