Trk receptors: roles in neuronal signal transduction.
- BiologyAnnual review of biochemistry
The most fascinating aspect of Trk receptor-mediated signaling is its interplay with signaling promoted by the pan-neurotrophin receptor p75NTR, which activates a distinct set of signaling pathways within cells that are in some instances synergistic and in other instances antagonistic to those activated by Trk receptors.
Neurotrophins and their receptors: signaling trios in complex biological systems
- BiologyCellular and Molecular Life Sciences CMLS
This review summarizes recent surprises of how ligand-receptor pairing may affect diverse developmental events, regulate response to injury and extend their influence on memory and learning.
Selectivity in neurotrophin signaling: theme and variations.
- BiologyAnnual review of neuroscience
Variations in neurotrophin signaling have revealed variations in the Ras/MAP kinase, PI3 kinases, and phospholipase C pathways, which transmit spatial and temporal information, which may represent a general mechanism eliciting specificity in growth factor responses.
Neurotrophins and their receptors: A convergence point for many signalling pathways
- BiologyNature Reviews Neuroscience
Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Modulation of neurotrophin signaling by monoclonal antibodies.
- BiologyHandbook of experimental pharmacology
The power of monoclonal antibodies to modulate neurotrophin signaling promises to turn the rich biological insights into novel human medicines.
Neurotrophin Signaling and Alzheimer’s Disease Neurodegeneration − Focus on BDNF/TrkB Signaling
- Biology, Chemistry
The importance of neurotrophin signaling in brain development is highlighted by findings showing that knockout mice for any one of the neurotrophins or their receptors are fatal or exhibit severe neural defects.
Neurotrophin-regulated signalling pathways
- BiologyPhilosophical Transactions of the Royal Society B: Biological Sciences
Three rare human genetic disorders, which result in deleterious effects on sensory perception, cognition and a variety of behaviours, have been shown to be attributable to mutations in brain-derived neurotrophic factor and two of the Trk receptors.
Neurotrophin signaling through the p75 neurotrophin receptor
- Biology, MedicineProgress in Neurobiology
Neurotrophin receptor homolog‐2 regulates nerve growth factor signaling
- BiologyJournal of neurochemistry
Results indicate that NRH2 utilizes intracellular mechanisms to not only regulate NGF binding to TrkA, but also specifically modulate Trk a receptor signaling, thus adding further layers of complexity and specificity to neurotrophin signaling.
SHOWING 1-10 OF 117 REFERENCES
Neurotrophin signal transduction in the nervous system
- BiologyCurrent Opinion in Neurobiology
Neurotrophins: roles in neuronal development and function.
- BiologyAnnual review of neuroscience
Neurotrophins regulate development, maintenance, and function of vertebrate nervous systems, and control synaptic function and synaptic plasticity, while continuing to modulate neuronal survival.
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
- BiologyThe EMBO journal
A close proximity of the two neurotrophin receptors within cell membranes is indicated, and it is suggested that the signalling pathways they initiate may interact soon after their activation.
Identification and Characterization of Novel Substrates of Trk Receptors in Developing Neurons
Phospholipase C-γ and Phosphoinositide 3-Kinase Mediate Cytoplasmic Signaling in Nerve Growth Cone Guidance
Cell Surface Trk Receptors Mediate NGF-Induced Survival While Internalized Receptors Regulate NGF-Induced Differentiation
- BiologyThe Journal of Neuroscience
It is shown that dynamin function is required for ligand-dependent endocytosis of Trk receptors, and interactions between Trk receptor tyrosine kinases and intracellular signaling molecules are dictated both by phosphotyrosine motifs within the receptors and by the intrACEllular location of phosphorylated receptors.
Role of Phosphoinositide 3-Kinase and Endocytosis in Nerve Growth Factor-Induced Extracellular Signal-Regulated Kinase Activation via Ras and Rap1
- Biology, ChemistryMolecular and Cellular Biology
It is suggested that PI3-K may be required for the signals initiated by TrkA internalization and demonstrate that specific endocytic events may distinguish ERK signaling via Rap1 and Ras.
Insulin Receptor Substrate (IRS)-1 and IRS-2 Are Tyrosine-phosphorylated and Associated with Phosphatidylinositol 3-Kinase in Response to Brain-derived Neurotrophic Factor in Cultured Cerebral Cortical Neurons*
- BiologyThe Journal of Biological Chemistry
It is found that insulin receptor substrate (IRS)-1 and -2 are involved in the BDNF signaling pathway that activates PI3-K, a component in the signaling pathway of BDNF that promotes differentiation and survival of various types of neurons in the central nervous system.
Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses
Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor
- Biology, ChemistryJournal of neuroscience research
The results suggest that c‐Abl may be recruited to the NGF receptor complex and be involved in regulating specific phosphorylation events that occur during neuronal differentiation.