Trivalent M-related protein as a component of next generation group A streptococcal vaccines

@inproceedings{Courtney2017TrivalentMP,
  title={Trivalent M-related protein as a component of next generation group A streptococcal vaccines},
  author={Harry S Courtney and Shannon E Niedermeyer and Thomas A Penfound and Claudia M Hohn and Adam Greeley and James B Dale},
  booktitle={Clinical and experimental vaccine research},
  year={2017}
}
PURPOSE There is a need to broaden protective coverage of M protein-based vaccines against group A streptococci (GAS) because coverage of the current 30-valent M protein vaccine does not extend to all emm types. An additional GAS antigen and virulence factor that could potentially extend vaccine coverage is M-related protein (Mrp). Previous work indicated that there are three structurally related families of Mrp (MrpI, MrpII, and MrpIII) and peptides of all three elicited bactericidal… CONTINUE READING

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