Trivalent Human Papillomavirus (HPV) VLP vaccine covering HPV type 58 can elicit high level of humoral immunity but also induce immune interference among component types.

@article{Zhang2010TrivalentHP,
  title={Trivalent Human Papillomavirus (HPV) VLP vaccine covering HPV type 58 can elicit high level of humoral immunity but also induce immune interference among component types.},
  author={Ting Zhang and Yufei Xu and Liang Qiao and Youchun Wang and Xue-ling Wu and Dongsheng Fan and Qinglin Peng and Xuemei Xu},
  journal={Vaccine},
  year={2010},
  volume={28 19},
  pages={3479-87}
}
Both Human Papillomavirus (HPV) type 16/18 bivalent vaccine and type 16/18/6/11 quadrivalent vaccine have been proved to be safe and effective, and licensed for public use. However, these two vaccines do not quite match the distribution of HPV types in China, Southeast Asia and Latin America, where HPV 58 is highly prevalent. Here we produced three types of virus-like particles (VLPs) in baculovirus expression system, formulated a trivalent vaccine containing HPV 16, 18, and 58 L1 VLPs and… CONTINUE READING

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