Tritium kinetic isotope effects on enzymatic decomposition of L-tryptophan

@inproceedings{Boroda2006TritiumKI,
  title={Tritium kinetic isotope effects on enzymatic decomposition of L-tryptophan},
  author={E. Boroda and R. Kański and Marianna Kańska},
  year={2006}
}
The enzyme tryptophanase (L-tryptophan indole lyase EC 4.1.99.1), TPase, catalyses the decomposition of L-Trp to the corresponding indole, pyruvic acid, and ammonia [12], (Scheme 1). Under certain conditions, there is a possibility of reverse reaction, leading to the formation of L-tryptophan. This enzyme also decomposes L-serine, L-cysteine, S-methyl-L-cysteine, and is often used in the synthesis of L-tryptophan [6]. In the literature, the mechanism of TPase catalysis are well documented [4, 8… CONTINUE READING