Trithorax monomethylates histone H3K4 and interacts directly with CBP to promote H3K27 acetylation and antagonize Polycomb silencing.

@article{Tie2014TrithoraxMH,
  title={Trithorax monomethylates histone H3K4 and interacts directly with CBP to promote H3K27 acetylation and antagonize Polycomb silencing.},
  author={Feng Tie and Rakhee Banerjee and Alina Saiakhova and Benny Howard and Kelsey E. Monteith and Peter C Scacheri and Michael S. Cosgrove and Peter J. Harte},
  journal={Development},
  year={2014},
  volume={141 5},
  pages={
          1129-39
        }
}
Trithorax (TRX) antagonizes epigenetic silencing by Polycomb group (PcG) proteins, stimulates enhancer-dependent transcription, and establishes a 'cellular memory' of active transcription of PcG-regulated genes. The mechanisms underlying these TRX functions remain largely unknown, but are presumed to involve its histone H3K4 methyltransferase activity. We report that the SET domains of TRX and TRX-related (TRR) have robust histone H3K4 monomethyltransferase activity in vitro and that Tyr3701 of… CONTINUE READING

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