Trithorax: A new homoeotic mutation of Drosophila melanogaster causing transformations of abdominal and thoracic imaginal segments

  title={Trithorax: A new homoeotic mutation of Drosophila melanogaster causing transformations of abdominal and thoracic imaginal segments},
  author={Philip W. Ingham and Robert J Whittle},
  journal={Molecular and General Genetics MGG},
SummaryA new homoeotic mutation, trithorax1 (trx1), of Drosophila melanogaster is described which causes intersegmental transformations in both the adult thorax and abdomen. Specifically, the metathorax and ventral prothorax are partially transformed to mesothroax, whilst abdominal segments are partially transformed towards the first abdominal segment. Three variables are shown to influence the expressivity of the mutant phenotype: (1) presence of wild type copies of the gene in the female… 

Trithorax: A new homoeotic mutation ofDrosophila melanogaster

  • P. Ingham
  • Biology
    Wilhelm Roux's archives of developmental biology
  • 2004
The phenotypes of different allelic combinations confirm that a decrease or loss of function of the locus is responsible for homoeotic transformations of the adult thoracic and abdominal segments and it is concluded that the latter is an allele oftrithorax.

Molecular Genetic Analysis of the Drosophila melanogaster Gene absent , small or homeotic discsl ( a s h l )

Analysis of ashl mutant flies that survive until the adult stage indicates that not only imaginal discand histoblast-derived tissues are affected but also that oogenesis requires ashl function, suggesting that trithorax is required for maintaining the normal UltrabithOrax transcription pattern.

A maternal effect mutation leading to deficiencies of organs and homeotic transformations in the adults ofDrosophila

  • F. Forquignon
  • Biology
    Wilhelm Roux's archives of developmental biology
  • 2004
SummaryThe temperature sensitive mutationfs(l)h is characterized at the restrictive temperature of 29°C by both a maternal effect responsible for the early embryonic lethality and pupal zygotic

Genetic interaction between homoeotic Sex combs reduced and Regulator of bithorax (or trithorax) genes of Drosophila melanogaster

  • Takashi Sato
  • Biology
    Roux's archives of developmental biology
  • 2004
It is concluded that the Rg-bx+ gene function is required for the optimal expression of the Scr gene in larval and imaginai cells.

Genetic studies of mutations at two loci of Drosophila melanogaster which cause a wide variety of homeotic transformations

The fact that these two defects, absence of specific discs and homeotic transformations of those same discs can be caused by mutations within a single gene suggests that the activity of the product of this gene is essential for normal imaginal disc cell proliferation.

Trithorax regulates systemic signaling during Drosophila imaginal disc regeneration

The chromatin-modification gene trithorax regulates a negative feedback loop that controls JNK signaling and Insulin-like Peptide 8 expression in damaged Drosophila imaginal discs.

Genetic Control of Body Segment Differentiation in Drosophila

Drosophila, like many other higher organisms, begins development as a tandem array of more or less identical body segments. During later development, these gradually diverge in morphology until the

Direct control of antennal identity by the spineless-aristapedia gene of Drosophila

It is found that Antp−ssa mitotic recombination clones in the distal antenna behave identically to Antp+ssa clones, and are transformed to second leg, demonstrating that the ssa antennal transformation is independent of Antp+, and suggesting that ss+ may itself directly define distal antennals identity.

Heat shock-induced phenocopies: Cis-regulation of the bithorax complex in Drosophila melanogaster

The results suggest that the heat shock interferes with the BX-C factor and not with the product of Polycomb, suggesting that the actual repression of the Ultraabdominal locus is due to at least two factors.

Genetic interactions between the Polycomb locus and the Antennapedia and Bithorax complexes of Drosophila

A model of regulation of the BX-C and the ANT-C genes during the imaginal cell proliferation is presented, in which the specification state is maintained by self-activation of a given selector gene and down modulation of other selector genes in the same cell.



Homoeotic and atavic mutations in insects

Genetic and developmental analyses of homoeotic mutations suggest that they are related in a sequence of regulatory steps, and this leads to an operational model for explaining genetic control of developmental pathways during ontogenesis and evolution.

Regulation and metamorphosis of the abdominal histoblasts ofDrosophila melanogaster

The development of the adult abdomen of Drosophila melanogaster was analyzed by histology, microcautery, and genetic strategies, indicating extensive pattern regulation and regeneration.

Developmental effects of exposing Drosophila embryos to ether vapour.

Drosophila embryos at precise developmental stages were exposed to ether vapour, causing defects primarily at the anterior of the embryo and disorganizing the arrangement of the segments.

Development and genetic analysis of bithorax phenocopies in Drosophila

This work has investigated whether the phenocopies of morphogenetic mutants of Drosophila also result from events taking place at the cellular level, and whether these events are connected to gene action.

Bristle patterns and compartment boundaries in the tarsi of Drosophila.

The results support the selector gene model of development (Garcia-Bellido, 1975) and emphasize that collaboration between polyclones is important in pattern formation.

Genetic control of wing disc development in Drosophila.

The genetic and developmental analysis of morphogenetic mutants in Drosophila has thrown some light on how the genetic information is selected and how it expresses itself in developmental operations, and a functional scheme is advanced showing how selector genes may become activated and control development.

A gene complex controlling segmentation in Drosophila

The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.

Heat shock induced phenocopies of dominant mutants of the bithorax complex in Drosophila melanogaster

SummaryHeat shock of 37°C applied to Drosophila embryos at blastoderm stage induces phenocopies of some dominant mutants of the bithorax complex. Heat shock might shut down functions of cis regulator