Trithorax: A new homoeotic mutation of Drosophila melanogaster causing transformations of abdominal and thoracic imaginal segments

@article{Ingham1980TrithoraxAN,
  title={Trithorax: A new homoeotic mutation of Drosophila melanogaster causing transformations of abdominal and thoracic imaginal segments},
  author={Philip W. Ingham and Robert J Whittle},
  journal={Molecular and General Genetics MGG},
  year={1980},
  volume={179},
  pages={607-614}
}
SummaryA new homoeotic mutation, trithorax1 (trx1), of Drosophila melanogaster is described which causes intersegmental transformations in both the adult thorax and abdomen. Specifically, the metathorax and ventral prothorax are partially transformed to mesothroax, whilst abdominal segments are partially transformed towards the first abdominal segment. Three variables are shown to influence the expressivity of the mutant phenotype: (1) presence of wild type copies of the gene in the female… 

Trithorax: A new homoeotic mutation ofDrosophila melanogaster

  • P. Ingham
  • Biology
    Wilhelm Roux's archives of developmental biology
  • 2004
The phenotypes of different allelic combinations confirm that a decrease or loss of function of the locus is responsible for homoeotic transformations of the adult thoracic and abdominal segments and it is concluded that the latter is an allele oftrithorax.

Molecular Genetic Analysis of the Drosophila melanogaster Gene absent , small or homeotic discsl ( a s h l )

Analysis of ashl mutant flies that survive until the adult stage indicates that not only imaginal discand histoblast-derived tissues are affected but also that oogenesis requires ashl function, suggesting that trithorax is required for maintaining the normal UltrabithOrax transcription pattern.

A maternal effect mutation leading to deficiencies of organs and homeotic transformations in the adults ofDrosophila

  • F. Forquignon
  • Biology
    Wilhelm Roux's archives of developmental biology
  • 2004
SummaryThe temperature sensitive mutationfs(l)h is characterized at the restrictive temperature of 29°C by both a maternal effect responsible for the early embryonic lethality and pupal zygotic

Genetic interaction between homoeotic Sex combs reduced and Regulator of bithorax (or trithorax) genes of Drosophila melanogaster

  • Takashi Sato
  • Biology
    Roux's archives of developmental biology
  • 2004
It is concluded that the Rg-bx+ gene function is required for the optimal expression of the Scr gene in larval and imaginai cells.

Genetic studies of mutations at two loci of Drosophila melanogaster which cause a wide variety of homeotic transformations

The fact that these two defects, absence of specific discs and homeotic transformations of those same discs can be caused by mutations within a single gene suggests that the activity of the product of this gene is essential for normal imaginal disc cell proliferation.

Trithorax regulates systemic signaling during Drosophila imaginal disc regeneration

The chromatin-modification gene trithorax regulates a negative feedback loop that controls JNK signaling and Insulin-like Peptide 8 expression in damaged Drosophila imaginal discs.

Genetic Control of Body Segment Differentiation in Drosophila

Drosophila, like many other higher organisms, begins development as a tandem array of more or less identical body segments. During later development, these gradually diverge in morphology until the

Direct control of antennal identity by the spineless-aristapedia gene of Drosophila

It is found that Antp−ssa mitotic recombination clones in the distal antenna behave identically to Antp+ssa clones, and are transformed to second leg, demonstrating that the ssa antennal transformation is independent of Antp+, and suggesting that ss+ may itself directly define distal antennals identity.

Heat shock-induced phenocopies: Cis-regulation of the bithorax complex in Drosophila melanogaster

The results suggest that the heat shock interferes with the BX-C factor and not with the product of Polycomb, suggesting that the actual repression of the Ultraabdominal locus is due to at least two factors.

Genetic interactions between the Polycomb locus and the Antennapedia and Bithorax complexes of Drosophila

A model of regulation of the BX-C and the ANT-C genes during the imaginal cell proliferation is presented, in which the specification state is maintained by self-activation of a given selector gene and down modulation of other selector genes in the same cell.
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