• Corpus ID: 3728472

Triterpenoid pristimerin induced HepG2 cells apoptosis through ROS-mediated mitochondrial dysfunction.

  title={Triterpenoid pristimerin induced HepG2 cells apoptosis through ROS-mediated mitochondrial dysfunction.},
  author={Yan Guo and Wei Zhang and Yan-yan Yan and Cun‐gen Ma and Xia Wang and Chen Wang and Jialong Zhao},
  journal={Journal of B.U.ON. : official journal of the Balkan Union of Oncology},
  volume={18 2},
  • Yan Guo, Wei Zhang, Jialong Zhao
  • Published 1 April 2013
  • Biology, Chemistry, Medicine
  • Journal of B.U.ON. : official journal of the Balkan Union of Oncology
PURPOSE To investigate the anticancer properties implicated in a natural triterpenoid (pristimerin)-induced apoptosis and inhibited proliferation in human hepatocellular carcinoma (HCC) HepG2 cell line. METHODS The cytotoxic activity of pristimerin in HepG2 cells was determined by MTT assay. Apoptotic morphology was observed by fluorescence microscope with Hoechst 33258 staining and percent apoptosis was measured by annexin V/PI double staining. DiOC6 for mitochondrial potential (ΔΨm) and… 

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