Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo

@article{Yamai2009TriterpenesAT,
  title={Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo},
  author={H. Yamai and N. Sawada and T. Yoshida and J. Seike and H. Takizawa and K. Kenzaki and T. Miyoshi and K. Kondo and Y. Bando and Y. Ohnishi and A. Tangoku},
  journal={International Journal of Cancer},
  year={2009},
  volume={125}
}
  • H. Yamai, N. Sawada, +8 authors A. Tangoku
  • Published 2009
  • Medicine
  • International Journal of Cancer
  • The antineoplastic effects of combinations of anticancer drugs (5‐fluorouracil, irinotecan and cisplatin) and triterpenes (ursolic acid, betulinic acid, oleanolic acid and a Japanese apricot extract (JAE) containing triterpenes) on esophageal squamous carcinoma cells were examined by the WST‐8 (2‐(2‐methoxy‐ 4‐nitrophenyl)‐3‐(4‐nitrophenyl)‐5‐(2,4‐disulfophenyl)‐2H‐tetrazolium, monosodium salt) assay in vitro and by an animal model in vivo. Triterpenes and JAE showed additive and synergistic… CONTINUE READING

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