Triterpenes as uncompetitive inhibitors of α-glucosidase from flowers of Punica granatum L.

@article{SalahElDine2014TriterpenesAU,
  title={Triterpenes as uncompetitive inhibitors of $\alpha$-glucosidase from flowers of Punica granatum L.},
  author={Riham Salah El Dine and Qiong Ma and Zeinab Abdel-Aziz Kandil and Ali M El-Halawany},
  journal={Natural Product Research},
  year={2014},
  volume={28},
  pages={2191 - 2194}
}
The α-glucosidase and maltase inhibitory effects of Punica granatum L. flowers (PGF) were investigated. The methanol extract (PGFMe), n-hexane extract (PGFH), chloroform extract (PGFC) and the remaining water fraction (PGFW) were assayed for their α-glucosidase and maltase inhibitory effects. PGFW showed potent α-glucosidase inhibition with IC50 of 0.8 μg/mL followed by PGFMe (IC50 of 4.0 μg/mL) then PGFC (IC50 of 5.21 μg/mL) in comparison to acarbose (0.9 μM). Due to its selectivity towards… Expand
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