Triterpene saponins from the roots of Clematis chinensis.

  title={Triterpene saponins from the roots of Clematis chinensis.},
  author={Yoshihiro Mimaki and Akihito Yokosuka and Mari Hamanaka and Chiseko Sakuma and Takao Yamori and Yutaka Sashida},
  journal={Journal of natural products},
  volume={67 9},
A saponin-enriched fraction prepared from the MeOH extract of the roots of Clematis chinensis showed cytotoxic activity against HL-60 promyelocytic leukemia cells, from which five new triterpene saponins based on oleanolic acid, along with three known saponins, were isolated. The structures of the new saponins were determined on the basis of spectroscopic analysis, including extensive 1D and 2D NMR data and hydrolysis followed by chromatographic and spectroscopic analysis. Among the isolated… CONTINUE READING