Triterpene Saponins from Cyclamen persicum

@article{MihciGaidi2010TriterpeneSF,
  title={Triterpene Saponins from Cyclamen persicum},
  author={Ghezala Mihci-Gaidi and David Pertuit and T. Miyamoto and J. Mirjolet and O. Duchamp and A. Mitaine-Offer and M. Lacaille‐Dubois},
  journal={Natural Product Communications},
  year={2010},
  volume={5}
}
A new triterpene saponin 3-O-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranosyl-16α-hydroxy-13β,28-epoxy-oleanan-30-al (1), along with four known triterpene glycosides (2-5) were isolated from Cyclamen persicum. Their structures were characterized by a combination of 1D- and 2D-NMR (1H-1H COSY, TOCSY, NOESY, HSQC, and HMBC) and MS spectrocopic data. The cytotoxicity of compounds 2 and 4 was evaluated using two human colon cancer cell lines HT-29 and HCT 116. 
A new flavone C-glycoside and a new bibenzyl from Bulbophyllum retusiusculum
TLDR
Compounds 1 and 2 showed no obvious cytotoxic activity against any five human tumour cell lines with IC50 values >40 μM and were isolated from the tubers of Bulbophyllum retusiusculum. Expand
Two New Triterpene Saponins from Cyclamen africanum Boiss. & Reuter
Two new oleanane-type triterpene saponins, afrocyclamins A and B (1 and 2, resp.), were isolated from a MeOH extract of the roots of Cyclamen africanum Boiss. & Reuter, together with three knownExpand
Two New Triterpene Saponins from Acanthophyllum laxiusculum
Two new triterpene glycosides, 1 and 2, together with three known ones, were isolated from roots of Acanthophyllum laxiusculum Schiman-Czeika. The structures of the new compounds were established byExpand
Cyclamen Trochopteranthum: Cytotoxic activity and possible adverse interactions including drugs and carcinogens
TLDR
Cyclamen may have a potential not only inhibition and/or induction of the metabolism of certain co-administered drugs but also development of toxicity, mutagenesis and malignant transformation due to induction or suppression of the CYP450s dependent drug metabolizing enzymes. Expand
Antimicrobial Effect of Cyclamen persicum Tuber Extracts Against Bacteria and Candida Species
TLDR
It was found that C. persicum tuber acetone, ethanol and methanol extracts have antibacterial effect on many Gram positive and Gram negative bacteria specially S. pyogenes, S. aureus, E. pneumoniae, P. mirabilis, K. aeruginosa and S. flexneri. Expand
Ex-Vivo and In-Vivo Assessment of Cyclamen europaeum Extract After Nasal Administration
TLDR
Histological studies showed that enhanced secretory activity in response to intranasal administration was not accompanied by any visible signs of injury, and the absence of mucosal permeation of saponins and negligible probability of C. europaeum saponin absorption in the course of a therapeutic application was demonstrated. Expand
Two SERK genes are markers of pluripotency in Cyclamen persicum Mill.
TLDR
It is proposed that the high expression of these genes in the trans-amplifying derivatives of the stem cells maintains a pluripotent condition leading to totipotency and, consequently, somatic embryogenesis. Expand
Cyclamen L. Inhibits Nitric Oxide Production in LPS-stimulated NSCLC Cells
TLDR
مع ذلك، تم عائلة Primulaceae في هذا الجنس بشكل سيئ لإمكاناته السامة للخلايا ومضادات السرطان. Expand

References

SHOWING 1-8 OF 8 REFERENCES
Saponins in Cyclamen species: Configuration of cyclamiretin C and structure of isocyclamin☆
TLDR
Five sapogenins and three saponins were identified in bulbs of 14 cytologically defined Cyclamen species and their structures were determined by means of mass, 1H and 13C NMR spectroscopy and the new saponin isocyclamin was identified. Expand
Molluscicidal triterpenoidal saponin from Lysimachia sikokiana.
The main molluscicidal activity of the methanol extract of Lysimachia sikokiana is due to several triterpenic saponins called sakuraso-saponins. The most active component was isolated from the aerialExpand
Triterpenoid saponins from Lysimachia davurica.
TLDR
Three new saponins were isolated from the whole plants of Lysimachia davurica and showed significant cytotoxicities against human A-2780 cells. Expand
Triterpene saponins from Cyclamen coum var. coum.
TLDR
Three new saponins, cyclaminorin, cyclacoumin and mirabilin lactone were isolated together with a known saponin, deglucocyclamin, and structure elucidattions were accomplished using both spectral (NMR, MS, IR) and chemical methods. Expand
Two new biologically active triterpenoidal saponins acylated with salicylic acid from Albizia adianthifolia.
TLDR
The crude saponin mixture (CSM), compounds 1 and 2 together with 3 and 4 (prosapogenins obtained from the mild alkaline hydrolysate of the CSM), were evaluated for immunomodulatory activity on the Jurkat T cell line and for hemolytic property against sheep erythrocytes. Expand
Triterpene saponins from Cyclamen trocopteranthum.
TLDR
Two new triterpene saponins were isolated from the tubers of Cyclamen trocopteranthum and showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells. Expand
Tumor inhibitors. XXI. Active principles of Acer negundo and Cyclamen persicum.
TLDR
An alcoholic extract of leaves and stems of Acer negundo L. was found to show significant inhibitory activity against sarcoma 180 in mice and systematic fractionation led to separation of a chroma-tographically homogeneous active acidic saponin fractions that showed significant inhibitories activity against the Walker intramuscular carcinosarcoma 256 tumor in rats. Expand
Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.
TLDR
The clonogenic assay was more sensitive when continuous drug exposures were utilized, although this was primarily related to the increased drug exposure time, and therefore it offers a valid, simple method of assessing chemosensitivity in established cell lines. Expand