Tristetraprolin regulates interleukin-6, which is correlated with tumor progression in patients with head and neck squamous cell carcinoma.

@article{Tubergen2011TristetraprolinRI,
  title={Tristetraprolin regulates interleukin-6, which is correlated with tumor progression in patients with head and neck squamous cell carcinoma.},
  author={Elizabeth A Van Tubergen and Robert Vander Broek and Julia Shin-Jung Lee and G T Wolf and Thomas E. Carey and Carol R. Bradford and Mark E. P. Prince and Keith Lough Kirkwood and Nisha J D'silva},
  journal={Cancer},
  year={2011},
  volume={117 12},
  pages={2677-89}
}
BACKGROUND Tumor-derived cytokines play a significant role in the progression of head and neck squamous cell carcinoma (HNSCC). Targeting proteins, such as tristetraprolin (TTP), that regulate multiple inflammatory cytokines may inhibit the progression of HNSCC. However, TTP's role in cancer is poorly understood. The goal of the current study was to determine whether TTP regulates inflammatory cytokines in patients with HNSCC. METHODS TTP messenger RNA (mRNA) and protein expression were… CONTINUE READING
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