Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling

@article{Marderosian2006TristetraprolinRC,
  title={Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling},
  author={M Marderosian and Alpana Sharma and Ann P. Funk and Raffi Vartanian and Janine Masri and Oak Don Jo and Joseph Gera},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={6277-6290}
}
The differential expression of the critical cell cycle control proteins cyclin D1 and c-myc has been shown to result in Akt-dependent hypersensitivity of tumor cells to mTOR inhibitors. We have previously demonstrated that the differential utilization of internal ribosome entry sites within the mRNAs of these transcripts allows maintenance of protein synthesis in the face of rapamycin (rapa) exposure in an Akt-dependent manner. Here, we demonstrate that in addition to this mechanism, cyclin D1… CONTINUE READING
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