Tristetraprolin mediates interferon-gamma mRNA decay.

@article{Ogilvie2009TristetraprolinMI,
  title={Tristetraprolin mediates interferon-gamma mRNA decay.},
  author={Rachel L Robison Ogilvie and Julius R Sternjohn and Bernd Rattenbacher and Irina A. Vlasova and Darlisha A Williams and Heidi H Hau and Perry J. Blackshear and Paul R Bohjanen},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 17},
  pages={11216-23}
}
Tristetraprolin (TTP) regulates expression at the level of mRNA decay of several cytokines, including the T cell-specific cytokine, interleukin-2. We performed experiments to determine whether another T cell-specific cytokine, interferon-gamma (IFN-gamma), is also regulated by TTP and found that T cell receptor-activated T cells from TTP knock-out mice overproduced IFN-gamma mRNA and protein compared with activated T cells from wild-type mice. The half-life of IFN-gamma mRNA was 23 min in anti… CONTINUE READING

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