Tristetraprolin impairs NF-kappaB/p65 nuclear translocation.

  title={Tristetraprolin impairs NF-kappaB/p65 nuclear translocation.},
  author={Yvonne M. Schichl and Ulrike Resch and Renate Hofer-Warbinek and Rainer de Martin},
  journal={The Journal of biological chemistry},
  volume={284 43},
Tristetraprolin (TTP) is a prototypic family member of CCCH-type tandem zinc-finger domain proteins that regulate mRNA destabilization in eukaryotic cells. TTP binds to AU-rich elements (AREs) in the 3'-untranslated region of certain mRNAs, including tumor necrosis factor alpha, granulocyte macrophage colony-stimulating factor, and immediate early response 3, thereby facilitating their ARE-mediated decay. Expression of TTP is up-regulated by a variety of agents, including inflammatory mediators… CONTINUE READING