Tristetraprolin downregulates the expression of both VEGF and COX-2 in human colon cancer.

@article{Cha2011TristetraprolinDT,
  title={Tristetraprolin downregulates the expression of both VEGF and COX-2 in human colon cancer.},
  author={Hee Jeong Cha and Hyun Hee Lee and Seoung Wan Chae and Wha Ja Cho and Young Min Kim and H S Choi and Dae Hwa Choi and Seok Won Jung and Young Joo Min and Byung Ju Lee and Soon Eun Park and Jeong Woo Park},
  journal={Hepato-gastroenterology},
  year={2011},
  volume={58 107-108},
  pages={790-5}
}
BACKGROUND/AIMS Although both VEGF and COX-2 are important factors influencing angiogenesis (and thus, carcinogenesis), the regulation of these factors in carcinogenesis remains poorly understood. The aim is to investigate the effects of tristetraprolin, an AU-rich element-binding protein on the expression of VEGF and COX-2 in human colon cancer cells. METHODOLOGY Expression of TTP, VEGF and COX-2 in the resected colorectal cancer surgical specimens were analyzed by immunohistochemistry… CONTINUE READING

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