Trisomy 7 and sex chromosome loss in human brain tissue.

@article{Heim1989Trisomy7A,
  title={Trisomy 7 and sex chromosome loss in human brain tissue.},
  author={Sverre Heim and Nils Mandahl and Yuesheng Jin and Susanne Str{\"o}mblad and Erika Lindstr{\"o}m and Leif G. Salford and Felix Mitelman},
  journal={Cytogenetics and cell genetics},
  year={1989},
  volume={52 3-4},
  pages={136-8}
}
Short-term cultures of nonneoplastic brain tissue from 11 patients, seven of whom had a malignant brain tumor, were cytogenetically examined. In only a single case was a wholly normal chromosome complement detected; the remaining ten cases exhibited mosaicism with clonal numerical aberrations found alongside cells carrying a normal karyotype. The abnormal clones were characterized by trisomy 7, the loss of the Y chromosome in men and an X chromosome in women, or by combinations thereof. No… CONTINUE READING

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