Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion.

@article{Loncarevic1999Trisomy2I,
  title={Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion.},
  author={Ivan F. Loncarevic and Barbara Roitzheim and J. Ritterbach and Susanne F Viehmann and Arndt Borkhardt and Fritz Lampert and Jochen Harbott},
  journal={Genes, chromosomes & cancer},
  year={1999},
  volume={24 3},
  pages={272-7}
}
TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence in situ hybridization (FISH) allowed us to identify chromosome anomalies in addition to the already existing t(12;21). Secondary aberrations were found in 29 out of 41 patients (71%) at initial… CONTINUE READING

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