Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.

  title={Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.},
  author={Ant{\^o}nio Francisco Alves da Silva and Filipe Brum Machado and {\'E}rika Cristina Pavarino and Joice Matos Biselli-P{\'e}rico and Bruna Lancia Zampieri and Ronaldo da Silva Francisco Junior and Pedro Thyago Mozer Rodrigues and Douglas Terra Machado and C{\'i}ntia Barros Santos-Rebouças and Maria M Gomes Fernandes and Susana M Chuva de Sousa Lopes and {\'A}lvaro Fabricio Lopes Rios and Enrique Medina-Acosta},
  journal={PloS one},
  volume={11 4},
The supernumerary chromosome 21 in Down syndrome differentially affects the methylation statuses at CpG dinucleotide sites and creates genome-wide transcriptional dysregulation of parental alleles, ultimately causing diverse pathologies. At present, it is unknown whether those effects are dependent or independent of the parental origin of the nondisjoined chromosome 21. Linkage analysis is a standard method for the determination of the parental origin of this aneuploidy, although it is… CONTINUE READING
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