Trisomy 11 in myeloid malignancies is associated with internal tandem duplication of both MLL and FLT3 genes.

Abstract

In 20 patients with myeloid malignancies and isolated trisomy 11 an internal tandem duplication of the MLL and FLT3 genes was observed in 41% and 31% of the cases, respectively; 80% of the FLT3+ cases showed MLL self-fusion. Concomitant presence of MLL and FLT3 anomalies could be relevant in determining the poor outcome of patients with acute myeloid… (More)

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Cite this paper

@article{RegeCambrin2005Trisomy1I, title={Trisomy 11 in myeloid malignancies is associated with internal tandem duplication of both MLL and FLT3 genes.}, author={Giovanna Rege-Cambrin and Emilia Giugliano and Lucienne Michaux and Michel Stul and Patrizia Scaravaglio and Anna Maria Serra and Giuseppe Saglio and Anne M Hagemeijer}, journal={Haematologica}, year={2005}, volume={90 2}, pages={262-4} }